Homer and Eddie

She's ruthless - He's witless - They're on the road together and falling apart at the seams

A mentally disabled man gets help from a sociopath when he tries to reunite with his dying father, who years earlier disowned him.

Trailers & more

Jim Belushi

Homer Lanza

Whoopi Goldberg

Eddie Cervi

John Waters

Robber #1

Robert Glaudini

Robber #2

James Thiel

Twin #1

Jeff Thiel

Twin #2 (as Jeffrey Thiel)

Andy Jarrell

Trucker

Anne Ramsey

Edna

Jim Mapp

Harmonica Player

Michelle Milantoni

Fat Woman in Pizza Joint

Mickey Jones

Man at Pizza Joint

Annie O'Donnell

Wife at Pizza Joint

Katherine Barrese

Waitress

Tad Horino

Mickey

Karen Black

Belle

Jack Goode Jr.

Tawdry Man

Ernestine McClendon

Esther

Pruitt Taylor Vince

Cashier